Packers-49ers odds: San Francisco favored in NFC heavyweight battle on SNF

Fresh off their bye, the Green Bay Packers (8-2) will visit the San Francisco 49ers (9-1) for the Week 12 Sunday Night Football matchup at Levi’s Stadium. Kickoff will be at 8:20 p.m. ET.

Packers at 49ers: Week 12 preview, betting trends and notes

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  • The Packers are only 1-3-1 against the spread over their last five games following a bye week. The total has gone Under in four of those five games.
  • In their last five games against teams with a winning record, the Packers are 5-0 ATS.
  • The 49ers are just 2-7-1 ATS in their last 10 home games against the Packers. In their last six meetings overall, however, the Packers are just 1-4-1 ATS vs. San Francisco.
  • The Packers have been very good on the road this year, going 3-1 ATS.
  • The total has gone Over in each of the 49ers’ last four games.
  • In the last nine head-to-head meetings, the total has gone Over in seven of them.

Packers at 49ers: Key injuries

49ers TE George Kittle is still recovering from a knee injury and is questionable to play Sunday. RB Matt Breida (ankle) is also uncertain to play, having missed time recently. LT Joe Staley (finger) and K Robbie Gould (quad) are dealing with injuries, as well.

Packers at 49ers: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 7 p.m. ET.

Prediction

Packers 27, 49ers 24

Moneyline ( ?)

The 49ers have hit a patch of struggles recently, falling to the Seattle Seahawks two weeks ago and nearly losing to the Arizona Cardinals in Week 11. The Packers aren’t perfect, but they’re healthy coming out of the bye and have Aaron Rodgers.

Bet the PACKERS (+145) to win this one outright, despite being the underdogs. They have the offensive line to neutralize the 49ers’ pass rush at least slightly and give Rodgers time.

Against the Spread ( ?)

The 49ers are 3.5-point home favorites over the Packers this weekend. Given their better record and home-field advantage, that’s no surprise. But with the Packers getting points, this bet is all the more enticing.

Bet the PACKERS (+3.5, -121) to cover the spread Sunday night, given their impressive 7-3 ATS record this season.

Over/Under ( ?)

The Over/Under is 46.5 points, but bet the OVER (-115). This game could turn into a shootout if the Packers throw the ball often early on.

As good as the 49ers defense has been, it has come back down to earth in recent weeks. They’ve given up 25, 27 and 26 points in their last three games after not allowing more than 20 through their first seven games.

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